TY - JOUR T1 - Fasting and Postprandial Activity of Brown Adipose Tissue in Healthy Men JF - Journal of Nuclear Medicine JO - J Nucl Med SP - 1407 LP - 1410 DO - 10.2967/jnumed.111.100701 VL - 53 IS - 9 AU - Anne Vrieze AU - Josefine E. Schopman AU - Wanda M. Admiraal AU - Maarten R. Soeters AU - Max Nieuwdorp AU - Hein J. Verberne AU - Frits Holleman Y1 - 2012/09/01 UR - http://jnm.snmjournals.org/content/53/9/1407.abstract N2 - The role of brown adipose tissue (BAT) in adult metabolism is poorly understood. This study aimed to examine the differential effects of an overnight fast and the postprandial state on BAT activity. Methods: We included 10 healthy, lean male volunteers. BAT uptake of glucose was visualized using 18F-FDG PET/CT during mild cold exposure. Each subject underwent PET/CT twice. The first scan was obtained after an overnight fast; the second after a standardized meal. Results: 18F-FDG uptake in BAT was observed in 6 of 10 volunteers. These subjects were found to have a higher maximal standardized uptake value when fasting (median, 13.1 g/mL; range, 6.1–27.6 g/mL) than when in the postprandial state (median, 6.8 g/mL; range, 2.1–13.4 g/mL) (P = 0.03). Conclusion: Cold-stimulated 18F-FDG uptake by BAT in humans is more pronounced during fasting. The lower maximal standardized uptake value in the postprandial state may be explained by increased insulin-stimulated glucose uptake in muscle. ER -