RT Journal Article
SR Electronic
T1 Fast Spiral SPECT with Stationary γ-Cameras and Focusing Pinholes
JF Journal of Nuclear Medicine
JO J Nucl Med
FD Society of Nuclear Medicine
SP 1292
OP 1299
DO 10.2967/jnumed.111.101899
VO 53
IS 8
A1 Vaissier, Pieter E.B.
A1 Goorden, Marlies C.
A1 Vastenhouw, Brendan
A1 van der Have, Frans
A1 Ramakers, Ruud M.
A1 Beekman, Freek J.
YR 2012
UL http://jnm.snmjournals.org/content/53/8/1292.abstract
AB Small-animal SPECT systems with stationary detectors and focusing multiple pinholes can achieve excellent resolution–sensitivity trade-offs. These systems are able to perform fast total-body scans by shifting the animal bed through the collimator using an automated xyz stage. However, so far, a large number of highly overlapping central fields of view have been used, at the cost of overhead time needed for animal repositioning and long image reconstruction times due to high numbers of projection views. Methods: To improve temporal resolution and reduce image reconstruction time for such scans, we have developed and tested spiral trajectories (STs) of the animal bed requiring fewer steps. In addition, we tested multiplane trajectories (MPTs) of the animal bed, which is the standard acquisition method of the U-SPECT-II system that is used in this study. Neither MPTs nor STs require rotation of the animal. Computer simulations and physical phantom experiments were performed for a wide range of numbers of bed positions. Furthermore, we tested STs in vivo for fast dynamic mouse scans. Results: We found that STs require less than half the number of bed positions of MPTs to achieve sufficient sampling. The reduced number of bed positions made it possible to perform a dynamic total-body bone scan and a dynamic hepatobiliary scan with time resolutions of 60 s and 15 s, respectively. Conclusion: STs open up new possibilities for high throughput and fast dynamic radio-molecular imaging.