PT - JOURNAL ARTICLE AU - Fidel J. Vos AU - Chantal P. Bleeker-Rovers AU - Bart Jan Kullberg AU - Eddy M.M. Adang AU - Wim J.G. Oyen TI - Cost-Effectiveness of Routine <sup>18</sup>F-FDG PET/CT in High-Risk Patients with Gram-Positive Bacteremia AID - 10.2967/jnumed.111.089714 DP - 2011 Nov 01 TA - Journal of Nuclear Medicine PG - 1673--1678 VI - 52 IP - 11 4099 - http://jnm.snmjournals.org/content/52/11/1673.short 4100 - http://jnm.snmjournals.org/content/52/11/1673.full SO - J Nucl Med2011 Nov 01; 52 AB - Gram-positive bacteremia has a high morbidity and mortality rate of approximately 30%. Delayed diagnosis of clinically silent metastatic infectious foci is an important indicator for a complicated outcome. 18F-FDG PET/CT allows detection of focal infection, resulting in lower relapse rates and mortality. Here, we present a cost-effectiveness analysis associated with introduction of 18F-FDG PET/CT for patients with gram-positive bacteremia. Methods: A cost-effectiveness analysis in a prospective 18F-FDG PET/CT group (n = 115) and matched control group (n = 230) was performed alongside a clinical study, the results of which were previously published. Mortality at 6 mo was considered the final effect outcome and was used in the denominator of the incremental cost-effectiveness ratio. Results: Mortality in the 18F-FDG PET/CT group was 19%, compared with 32% in the control group (P &lt; 0.01). Incremental costs of 18F-FDG PET/CT were $9,454 (95% confidence interval [CI], $3,963–$14,947), mainly because of admission (mean, $6,631; 95% CI, $1,449–$11,814). Additional costs were related to echocardiography (P &lt; 0.01), not to 18F-FDG PET/CT (P = 0.8). The mean incremental costs of the 18F-FDG PET/CT strategy estimated by stratification for endocarditis were $5,277 per patient (95% CI, $429–$10,123; P = 0.03). The point estimate of the incremental cost-effectiveness ratio is $72,487 per prevented death (95% CI, $11,388–$323,379). Conclusion: Introduction of a diagnostic regimen including routine 18F-FDG PET/CT decreases morbidity and mortality. The cost increase is due to in-hospital treatment of metastatic infectious foci. Costs per prevented death, $72,487, are within the range that is considered to be efficient by Dutch guidelines. Patients with high-risk gram-positive bacteremia therefore should have easy access to 18F-FDG PET/CT to enable early detection of metastatic infectious disease.