RT Journal Article
SR Electronic
T1 Widespread and Prolonged Increase in (<em>R</em>)-<sup>11</sup>C-PK11195 Binding After Traumatic Brain Injury
JF Journal of Nuclear Medicine
JO J Nucl Med
FD Society of Nuclear Medicine
SP 1235
OP 1239
DO 10.2967/jnumed.110.084061
VO 52
IS 8
A1 Folkersma, Hedy
A1 Boellaard, Ronald
A1 Yaqub, Maqsood
A1 Kloet, Reina W.
A1 Windhorst, Albert D.
A1 Lammertsma, Adriaan A.
A1 Vandertop, W. Peter
A1 van Berckel, Bart N.M.
YR 2011
UL http://jnm.snmjournals.org/content/52/8/1235.abstract
AB Our objective was to measure (R)-11C-PK11195 binding as an indirect marker of neuronal damage after traumatic brain injury (TBI). Methods: Dynamic (R)-11C-PK11195 PET scans were acquired for 8 patients 6 mo after TBI and for 7 age-matched healthy controls. (R)-11C-PK11195 binding was assessed using the simplified reference tissue model. Because of widespread traumatic changes in TBI, an anatomic reference region could not be defined. Therefore, supervised cluster analysis was used to generate an appropriate reference tissue input. Results: Increased whole-brain binding of (R)-11C-PK11195 was observed in TBI patients. Regional analysis indicated that increased (R)-11C-PK11195 binding was widespread over the brain. Conclusion: Six months after TBI, there was a prolonged and widespread increase in (R)-11C-PK11195 binding, which is indicative of diffuse neuronal damage.