PT  - JOURNAL ARTICLE
AU  - Hedy Folkersma
AU  - Ronald Boellaard
AU  - Maqsood Yaqub
AU  - Reina W. Kloet
AU  - Albert D. Windhorst
AU  - Adriaan A. Lammertsma
AU  - W. Peter Vandertop
AU  - Bart N.M. van Berckel
TI  - Widespread and Prolonged Increase in (<em>R</em>)-<sup>11</sup>C-PK11195 Binding After Traumatic Brain Injury
AID  - 10.2967/jnumed.110.084061
DP  - 2011 Aug 01
TA  - Journal of Nuclear Medicine
PG  - 1235--1239
VI  - 52
IP  - 8
4099  - http://jnm.snmjournals.org/content/52/8/1235.short
4100  - http://jnm.snmjournals.org/content/52/8/1235.full
SO  - J Nucl Med2011 Aug 01; 52
AB  - Our objective was to measure (R)-11C-PK11195 binding as an indirect marker of neuronal damage after traumatic brain injury (TBI). Methods: Dynamic (R)-11C-PK11195 PET scans were acquired for 8 patients 6 mo after TBI and for 7 age-matched healthy controls. (R)-11C-PK11195 binding was assessed using the simplified reference tissue model. Because of widespread traumatic changes in TBI, an anatomic reference region could not be defined. Therefore, supervised cluster analysis was used to generate an appropriate reference tissue input. Results: Increased whole-brain binding of (R)-11C-PK11195 was observed in TBI patients. Regional analysis indicated that increased (R)-11C-PK11195 binding was widespread over the brain. Conclusion: Six months after TBI, there was a prolonged and widespread increase in (R)-11C-PK11195 binding, which is indicative of diffuse neuronal damage.