TY - JOUR T1 - Imaging Targets of the Sympathetic Nervous System of the Heart: Translational Considerations JF - Journal of Nuclear Medicine JO - J Nucl Med SP - 1167 LP - 1170 DO - 10.2967/jnumed.110.084228 VL - 52 IS - 8 AU - Frank M. Bengel Y1 - 2011/08/01 UR - http://jnm.snmjournals.org/content/52/8/1167.abstract N2 - The usefulness of imaging the cardiac sympathetic nervous system is increasingly supported by prospective clinical studies. The future success of this molecular imaging technique, however, will depend on careful design of additional trials. But preclinical and clinical use requires a thorough understanding of the underlying biology, which defines the relationship between neuronal tracer kinetics, disease mechanisms, and appropriate study interpretation. This review focuses on basic methodologic aspects considered relevant for successful continuation of the translation of cardiac neuronal imaging from a research tool toward a clinical test. ER -