TY - JOUR T1 - Introducing Parametric Fusion PET/MRI of Primary Prostate Cancer JF - Journal of Nuclear Medicine JO - J Nucl Med SP - 546 LP - 551 DO - 10.2967/jnumed.111.091421 VL - 53 IS - 4 AU - Hyunjin Park AU - David Wood AU - Hero Hussain AU - Charles R. Meyer AU - Rajal B. Shah AU - Timothy D. Johnson AU - Thomas Chenevert AU - Morand Piert Y1 - 2012/04/01 UR - http://jnm.snmjournals.org/content/53/4/546.abstract N2 - We assessed the performance of parametric fusion PET/MRI based on 11C-choline PET/CT and apparent diffusion coefficient (ADC) maps derived from diffusion-weighted MRI for the identification of primary prostate cancer. Methods: 11C-choline PET/CT and MRI were performed in 17 patients with untreated primary prostate cancer, followed by prostatectomy. Registration of in vivo imaging with histology was achieved using a mutual-information objective function and by performing ex vivo MRI of the prostatectomy specimen (obtained at 3 T) and whole-mount sectioning with block-face photography as intermediate steps. Data analysis included volumetrically registered whole-mount histology with Gleason scoring, 11C-choline, and ADC data (obtained at 1.5 T). Volumes of interest were defined on the basis of histologically proven tumor tissue to calculate tumor–to–benign prostate background ratios (TBRs) for 11C-choline, ADC, and a derived fusion PET/MRI parameter calculating the quotient of 11C-choline over ADC (PCHOL/ADC). Results: Fifty-one tumor nodules were identified at pathology. The TBRs for 11C-choline (P < 0.05) and PCHOL/ADC (P < 0.005) were significantly higher in prostate cancers with a Gleason score of ≥3 + 4 than with a Gleason score of ≤3 + 3 disease and controls. For Gleason ≥ 3 + 4, the ADC TBRs were significantly lower than controls and Gleason ≤ 3 + 3 disease (P < 0.05). The absolute value of TBRs obtained from Gleason ≥ 3 + 4 cancers increased from ADC to 11C-choline PET/CT and from 11C-choline PET/CT to PCHOL/ADC, with each step being statistically significant. Conclusion: Our data indicate that parametric PET/MRI using PCHOL/ADC improves lesion-to-background contrast (TBRs) of Gleason ≥ 3 + 4 disease, compared with 11C-choline PET/CT or diffusion-weighted MRI, and thus hold promise that parametric imaging performed on hybrid PET/MRI may further improve identification and localization of significant primary prostate cancer. ER -