TY - JOUR T1 - Risk Stratification of Gallbladder Polyps (1–2 cm) for Surgical Intervention with <sup>18</sup>F-FDG PET/CT JF - Journal of Nuclear Medicine JO - J Nucl Med SP - 353 LP - 358 DO - 10.2967/jnumed.111.093948 VL - 53 IS - 3 AU - Jaehoon Lee AU - Mijin Yun AU - Kyoung-Sik Kim AU - Jong-Doo Lee AU - Chun K. Kim Y1 - 2012/03/01 UR - http://jnm.snmjournals.org/content/53/3/353.abstract N2 - We assessed the value of 18F-FDG uptake in the gallbladder polyp (GP) in risk stratification for surgical intervention and the optimal cutoff level of the parameters derived from GP 18F-FDG uptake for differentiating malignant from benign etiologies in a select, homogeneous group of patients with 1- to 2-cm GPs. Methods: Fifty patients with 1- to 2-cm GPs incidentally found on the CT portion of PET/CT were retrospectively analyzed. All patients had histologic diagnoses. GP 18F-FDG activity was visually scored positive (≥liver) or negative (&lt;liver). Maximal standardized uptake value of the GP (SUVgp) and ratio of SUVgp to mean SUV of the liver (GP/L ratio) were also measured. Univariate and multivariate logistic regression analyses were performed to determine the utility of patient and clinical variables—that is, sex, age, gallstone, polyp size, and three 18F-FDG–related parameters in risk stratification. Results: Twenty GPs were classified as malignant and 30 as benign. Multivariate analyses showed that the age and all parameters (visual criteria, SUVgp, and GP/L) related to 18F-FDG uptake were significant risk factors, with the GP/L being the most significant. The sex, size of GPs, and presence of concurrent gallstones were found to be insignificant. Conclusion: 18F-FDG uptake in a GP is a strong risk factor that can be used to determine the necessity of surgical intervention more effectively than other known risk factors. However, all criteria derived from 18F-FDG uptake presented in this series may be applicable to the assessment of 1- to 2-cm GPs. ER -