RT Journal Article
SR Electronic
T1 What Can Be Seen by <sup>18</sup>F-FDG PET in Atherosclerosis Imaging? The Effect of Foam Cell Formation on <sup>18</sup>F-FDG Uptake to Macrophages In Vitro
JF Journal of Nuclear Medicine
JO J Nucl Med
FD Society of Nuclear Medicine
SP 55
OP 58
DO 10.2967/jnumed.111.092866
VO 53
IS 1
A1 Ogawa, Mikako
A1 Nakamura, Satoki
A1 Saito, Yuriko
A1 Kosugi, Mutsumi
A1 Magata, Yasuhiro
YR 2012
UL http://jnm.snmjournals.org/content/53/1/55.abstract
AB 18F-FDG PET is a promising tool for detecting vulnerable plaques, depending on the extent of macrophage infiltration; however, it is still not clear which stage of the lesion can be detected by 18F-FDG PET. Methods: In this study, we investigated the effect of foam cell formation on 18F-FDG uptake using cultured mouse peritoneal macrophages. Results: 18F-FDG accumulation was increased by foam cell formation, but the uptake was decreased to the control level after complete differentiation to foam cells. Changes in hexokinase activity tended to accompany changes in 18F-FDG uptake. In contrast, changes in glucose-6-phosphatase activity and glucose transporter 1 expression did not parallel 18F-FDG uptake. Conclusion: Our results suggest that 18F-FDG PET detects the early stage of foam cell formation in atherosclerosis.