RT Journal Article
SR Electronic
T1 Need for Standardization of <sup>18</sup>F-FDG PET/CT for Treatment Response Assessments
JF Journal of Nuclear Medicine
JO J Nucl Med
FD Society of Nuclear Medicine
SP 93S
OP 100S
DO 10.2967/jnumed.110.085662
VO 52
IS Supplement 2
A1 Boellaard, Ronald
YR 2011
UL http://jnm.snmjournals.org/content/52/Supplement_2/93S.abstract
AB Many factors affect standardized uptake values (SUVs) in 18F-FDG PET/CT. The use of the SUV from a single PET scan in multicenter studies requires the standardization of 18F-FDG PET/CT procedures. In the context of treatment response assessments (repeated PET scans), many factors may seem to have minor effects on percentage changes in SUVs, provided that imaging procedures are executed in a consistent manner for each subject. However, the use of 18F-FDG PET/CT in a nonstandardized manner will result in unknown biases and reproducibilities of SUVs and SUV-based response measures. This article provides an overview of the need for standardization in relation to the specific use of SUVs and SUV changes in studies of treatment response assessments.