PT  - JOURNAL ARTICLE
AU  - Boellaard, Ronald
TI  - Need for Standardization of <sup>18</sup>F-FDG PET/CT for Treatment Response Assessments
AID  - 10.2967/jnumed.110.085662
DP  - 2011 Dec 01
TA  - Journal of Nuclear Medicine
PG  - 93S--100S
VI  - 52
IP  - Supplement 2
4099  - http://jnm.snmjournals.org/content/52/Supplement_2/93S.short
4100  - http://jnm.snmjournals.org/content/52/Supplement_2/93S.full
SO  - J Nucl Med2011 Dec 01; 52
AB  - Many factors affect standardized uptake values (SUVs) in 18F-FDG PET/CT. The use of the SUV from a single PET scan in multicenter studies requires the standardization of 18F-FDG PET/CT procedures. In the context of treatment response assessments (repeated PET scans), many factors may seem to have minor effects on percentage changes in SUVs, provided that imaging procedures are executed in a consistent manner for each subject. However, the use of 18F-FDG PET/CT in a nonstandardized manner will result in unknown biases and reproducibilities of SUVs and SUV-based response measures. This article provides an overview of the need for standardization in relation to the specific use of SUVs and SUV changes in studies of treatment response assessments.