PT - JOURNAL ARTICLE AU - Catherine M. Lockhart AU - Lawrence R. MacDonald AU - Adam M. Alessio AU - Wendy A. McDougald AU - Robert K. Doot AU - Paul E. Kinahan TI - Quantifying and Reducing the Effect of Calibration Error on Variability of PET/CT Standardized Uptake Value Measurements AID - 10.2967/jnumed.110.083865 DP - 2011 Feb 01 TA - Journal of Nuclear Medicine PG - 218--224 VI - 52 IP - 2 4099 - http://jnm.snmjournals.org/content/52/2/218.short 4100 - http://jnm.snmjournals.org/content/52/2/218.full SO - J Nucl Med2011 Feb 01; 52 AB - The purpose of this study was to measure the errors introduced by regular calibration of PET/CT scanners and to minimize the effect of calibration error on standardized uptake value measurements. Methods: Global calibration factors from 2 PET/CT scanners were recorded for 3.5 and 1.8 y, comparing manufacturer-recommended protocols with modified protocols to evaluate error contributions due to operator-influenced procedures. Dose calibrator measurements were evaluated using National Institute of Standards and Technology–traceable sources. Results: Dose calibrator variability was less than 1%, although there was a consistent bias. Global scaling variability was reduced from 6% to 4% for scanner 1 and from 11% to 4% for scanner 2 when quality assurance and quality control procedures were applied to the calibration protocol. When calibrations were done using a 68Ge/68Ga phantom, the variability for both scanners was reduced to approximately 3%. Conclusion: Applying quality assurance and quality control procedures to scanner calibration reduces variability, but there is a still a residual longitudinal scanner variability of 3%–4%. The procedures proposed here reduce the impact of operator error on scanner calibration and thereby minimize longitudinal variability in standarized uptake value measurements.