TY - JOUR T1 - Examination of <sup>11</sup>C-Methionine Metabolism by the Standardized Uptake Value in the Normal Brain of Children JF - Journal of Nuclear Medicine JO - J Nucl Med SP - 201 LP - 205 DO - 10.2967/jnumed.110.082875 VL - 52 IS - 2 AU - Takashi Nagata AU - Naohiro Tsuyuguchi AU - Takehiro Uda AU - Yuzo Terakawa AU - Toshihiro Takami AU - Kenji Ohata Y1 - 2011/02/01 UR - http://jnm.snmjournals.org/content/52/2/201.abstract N2 - The aim of this study was to determine the uptake of L-[methyl-11C]-methionine (11C-MET) in the normal brain of patients younger than 20 y, to facilitate more accurate diagnoses in young patients. Methods: Eighty-two patients were categorized into 4 groups according to their age. They underwent 11C-MET PET, and a standardized uptake value (SUV) was determined for different brain regions including the frontal lobe, parietal lobe, cerebellum, and brain stem. Results: Compared with all other parts of the brain, the cerebellum had the highest SUV. A tendency for a positive relationship between SUV and age was found in all regions, and a significant relationship with SUV was found in the frontal lobe and cerebellum. Conclusion: The character of SUV in the normal brains of children is different from that of adults, and these normal SUV data will play an important role as a critical reference value. ER -