TY - JOUR T1 - Internal Pair Production of <sup>90</sup>Y Permits Hepatic Localization of Microspheres Using Routine PET: Proof of Concept JF - Journal of Nuclear Medicine JO - J Nucl Med SP - 72 LP - 76 DO - 10.2967/jnumed.110.080986 VL - 52 IS - 1 AU - Vanessa L. Gates AU - Abdulredha A.H. Esmail AU - Karen Marshall AU - Stewart Spies AU - Riad Salem Y1 - 2011/01/01 UR - http://jnm.snmjournals.org/content/52/1/72.abstract N2 - Radioembolization with 90Y microspheres represents a novel transarterial radiation treatment for liver tumors. The purpose of this pilot study was to evaluate the findings of postimplantation PET/CT of 90Y glass microspheres. Methods: Three patients with hepatocellular carcinoma and 2 patients with liver metastases (1 neuroendocrine, 1 colorectal) underwent PET/CT after radioembolization. Four patients underwent imaging at 1 mo to assess response and confirm PET/CT findings; 1 patient underwent PET/CT at 4 d after 90Y implantation. Patients were followed for adverse events. Results: Standard PET/CT enabled the localization of 90Y glass microspheres for all patients. None of the patients experienced adverse events related to nontarget deposition. Conclusion: Standard PET/CT may be used to assess the localization of 90Y glass microspheres. This approach provides a simple, rapid, and universally applicable method of confirming microsphere deposition. With further validation, this technique may potentially become the standard of care for confirming microsphere distribution. ER -