PT  - JOURNAL ARTICLE
AU  - Vanessa L. Gates
AU  - Abdulredha A.H. Esmail
AU  - Karen Marshall
AU  - Stewart Spies
AU  - Riad Salem
TI  - Internal Pair Production of <sup>90</sup>Y Permits Hepatic Localization of Microspheres Using Routine PET: Proof of Concept
AID  - 10.2967/jnumed.110.080986
DP  - 2011 Jan 01
TA  - Journal of Nuclear Medicine
PG  - 72--76
VI  - 52
IP  - 1
4099  - http://jnm.snmjournals.org/content/52/1/72.short
4100  - http://jnm.snmjournals.org/content/52/1/72.full
SO  - J Nucl Med2011 Jan 01; 52
AB  - Radioembolization with 90Y microspheres represents a novel transarterial radiation treatment for liver tumors. The purpose of this pilot study was to evaluate the findings of postimplantation PET/CT of 90Y glass microspheres. Methods: Three patients with hepatocellular carcinoma and 2 patients with liver metastases (1 neuroendocrine, 1 colorectal) underwent PET/CT after radioembolization. Four patients underwent imaging at 1 mo to assess response and confirm PET/CT findings; 1 patient underwent PET/CT at 4 d after 90Y implantation. Patients were followed for adverse events. Results: Standard PET/CT enabled the localization of 90Y glass microspheres for all patients. None of the patients experienced adverse events related to nontarget deposition. Conclusion: Standard PET/CT may be used to assess the localization of 90Y glass microspheres. This approach provides a simple, rapid, and universally applicable method of confirming microsphere deposition. With further validation, this technique may potentially become the standard of care for confirming microsphere distribution.