RT Journal Article SR Electronic T1 18F-FDG PET Reveals Frontotemporal Dysfunction in Children with Fever-Induced Refractory Epileptic Encephalopathy JF Journal of Nuclear Medicine JO J Nucl Med FD Society of Nuclear Medicine SP 40 OP 47 DO 10.2967/jnumed.110.077214 VO 52 IS 1 A1 Michel Mazzuca A1 Isabelle Jambaque A1 Lucie Hertz-Pannier A1 Viviane Bouilleret A1 Frederique Archambaud A1 Verne Caviness A1 Sebastian Rodrigo A1 Olivier Dulac A1 Catherine Chiron YR 2011 UL http://jnm.snmjournals.org/content/52/1/40.abstract AB Fever-induced refractory epileptic encephalopathy in school-age children (FIRES) is a recently described epileptic entity whose etiology remains unknown. Brain abnormalities shown by MRI are usually limited to mesial-temporal structures and do not account for the catastrophic neuropsychologic findings. Methods: We conducted FIRES studies in 8 patients, aged 6–13 y, using 18F-FDG PET to disclose eventual neocortical dysfunction. Voxel-based analyses of cerebral glucose metabolism were performed using statistical parametric mapping and an age-matched control group. Results: Group analysis revealed a widespread interictal hypometabolic network including the temporoparietal and orbitofrontal cortices bilaterally. The individual analyses in patients identified hypometabolic areas corresponding to the predominant electroencephalograph foci and neuropsychologic deficits involving language, behavior, and memory. Conclusion: Despite clinical heterogeneity, 18F-FDG PET reveals a common network dysfunction in patients with sequelae due to fever-induced refractory epileptic encephalopathy.