PT  - JOURNAL ARTICLE
AU  - Michel Mazzuca
AU  - Isabelle Jambaque
AU  - Lucie Hertz-Pannier
AU  - Viviane Bouilleret
AU  - Frederique Archambaud
AU  - Verne Caviness
AU  - Sebastian Rodrigo
AU  - Olivier Dulac
AU  - Catherine Chiron
TI  - <sup>18</sup>F-FDG PET Reveals Frontotemporal Dysfunction in Children with Fever-Induced Refractory Epileptic Encephalopathy
AID  - 10.2967/jnumed.110.077214
DP  - 2011 Jan 01
TA  - Journal of Nuclear Medicine
PG  - 40--47
VI  - 52
IP  - 1
4099  - http://jnm.snmjournals.org/content/52/1/40.short
4100  - http://jnm.snmjournals.org/content/52/1/40.full
SO  - J Nucl Med2011 Jan 01; 52
AB  - Fever-induced refractory epileptic encephalopathy in school-age children (FIRES) is a recently described epileptic entity whose etiology remains unknown. Brain abnormalities shown by MRI are usually limited to mesial-temporal structures and do not account for the catastrophic neuropsychologic findings. Methods: We conducted FIRES studies in 8 patients, aged 6–13 y, using 18F-FDG PET to disclose eventual neocortical dysfunction. Voxel-based analyses of cerebral glucose metabolism were performed using statistical parametric mapping and an age-matched control group. Results: Group analysis revealed a widespread interictal hypometabolic network including the temporoparietal and orbitofrontal cortices bilaterally. The individual analyses in patients identified hypometabolic areas corresponding to the predominant electroencephalograph foci and neuropsychologic deficits involving language, behavior, and memory. Conclusion: Despite clinical heterogeneity, 18F-FDG PET reveals a common network dysfunction in patients with sequelae due to fever-induced refractory epileptic encephalopathy.