RT Journal Article
SR Electronic
T1 Folic Acid Conjugates for Nuclear Imaging of Folate Receptor–Positive Cancer
JF Journal of Nuclear Medicine
JO J Nucl Med
FD Society of Nuclear Medicine
SP 1
OP 4
DO 10.2967/jnumed.110.076018
VO 52
IS 1
A1 Cristina Müller
A1 Roger Schibli
YR 2011
UL http://jnm.snmjournals.org/content/52/1/1.abstract
AB The folate receptor (FR) is overexpressed on a variety of tumor types, whereas its distribution in normal tissues and organs is highly limited. Exploration of the utility of the FR revealed its promising potential for targeting with folate-based radiopharmaceuticals. Herein, we report the principle of the FR-targeting strategy and summarize the development of several folic acid radioconjugates useful for SPECT and PET of cancer diseases. The potential applicability of folate radiopharmaceuticals for FR-targeted radionuclide therapy is also discussed.