PT  - JOURNAL ARTICLE
AU  - Cristina Müller
AU  - Roger Schibli
TI  - Folic Acid Conjugates for Nuclear Imaging of Folate Receptor–Positive Cancer
AID  - 10.2967/jnumed.110.076018
DP  - 2011 Jan 01
TA  - Journal of Nuclear Medicine
PG  - 1--4
VI  - 52
IP  - 1
4099  - http://jnm.snmjournals.org/content/52/1/1.short
4100  - http://jnm.snmjournals.org/content/52/1/1.full
SO  - J Nucl Med2011 Jan 01; 52
AB  - The folate receptor (FR) is overexpressed on a variety of tumor types, whereas its distribution in normal tissues and organs is highly limited. Exploration of the utility of the FR revealed its promising potential for targeting with folate-based radiopharmaceuticals. Herein, we report the principle of the FR-targeting strategy and summarize the development of several folic acid radioconjugates useful for SPECT and PET of cancer diseases. The potential applicability of folate radiopharmaceuticals for FR-targeted radionuclide therapy is also discussed.