RT Journal Article
SR Electronic
T1 Multimodality Imaging of Myocardial Injury and Remodeling
JF Journal of Nuclear Medicine
JO J Nucl Med
FD Society of Nuclear Medicine
SP 107S
OP 121S
DO 10.2967/jnumed.109.068221
VO 51
IS Supplement 1
A1 Christopher M. Kramer
A1 Albert J. Sinusas
A1 David E. Sosnovik
A1 Brent A. French
A1 Frank M. Bengel
YR 2010
UL http://jnm.snmjournals.org/content/51/Supplement_1/107S.abstract
AB Advances in cardiovascular molecular imaging have come at a rapid pace over the last several years. Multiple approaches have been taken to better understand the structural, molecular, and cellular events that underlie the progression from myocardial injury to myocardial infarction (MI) and, ultimately, to congestive heart failure. Multimodality molecular imaging including SPECT, PET, cardiac MRI, and optical approaches is offering new insights into the pathophysiology of MI and left ventricular remodeling in small-animal models. Targets that are being probed include, among others, angiotensin receptors, matrix metalloproteinases, integrins, apoptosis, macrophages, and sympathetic innervation. It is only a matter of time before these advances are applied in the clinical setting to improve post-MI prognostication and identify appropriate therapies in patients to prevent the onset of congestive heart failure.