PT  - JOURNAL ARTICLE
AU  - Christopher M. Kramer
AU  - Albert J. Sinusas
AU  - David E. Sosnovik
AU  - Brent A. French
AU  - Frank M. Bengel
TI  - Multimodality Imaging of Myocardial Injury and Remodeling
AID  - 10.2967/jnumed.109.068221
DP  - 2010 May 01
TA  - Journal of Nuclear Medicine
PG  - 107S--121S
VI  - 51
IP  - Supplement 1
4099  - http://jnm.snmjournals.org/content/51/Supplement_1/107S.short
4100  - http://jnm.snmjournals.org/content/51/Supplement_1/107S.full
SO  - J Nucl Med2010 May 01; 51
AB  - Advances in cardiovascular molecular imaging have come at a rapid pace over the last several years. Multiple approaches have been taken to better understand the structural, molecular, and cellular events that underlie the progression from myocardial injury to myocardial infarction (MI) and, ultimately, to congestive heart failure. Multimodality molecular imaging including SPECT, PET, cardiac MRI, and optical approaches is offering new insights into the pathophysiology of MI and left ventricular remodeling in small-animal models. Targets that are being probed include, among others, angiotensin receptors, matrix metalloproteinases, integrins, apoptosis, macrophages, and sympathetic innervation. It is only a matter of time before these advances are applied in the clinical setting to improve post-MI prognostication and identify appropriate therapies in patients to prevent the onset of congestive heart failure.