PT - JOURNAL ARTICLE AU - Alexander R. Haug AU - Christoph J. Auernhammer AU - Björn Wängler AU - Gerwin P. Schmidt AU - Christopher Uebleis AU - Burkhard Göke AU - Paul Cumming AU - Peter Bartenstein AU - Reinhold Tiling AU - Marcus Hacker TI - <sup>68</sup>Ga-DOTATATE PET/CT for the Early Prediction of Response to Somatostatin Receptor–Mediated Radionuclide Therapy in Patients with Well-Differentiated Neuroendocrine Tumors AID - 10.2967/jnumed.110.075002 DP - 2010 Sep 01 TA - Journal of Nuclear Medicine PG - 1349--1356 VI - 51 IP - 9 4099 - http://jnm.snmjournals.org/content/51/9/1349.short 4100 - http://jnm.snmjournals.org/content/51/9/1349.full SO - J Nucl Med2010 Sep 01; 51 AB - We aimed to evaluate 68Ga-DOTATATE PET/CT for the early prediction of time to progression and clinical outcome after a first cycle of peptide receptor radionuclide treatment (PRRT) in a cohort of patients with well-differentiated neuroendocrine tumors. Methods: Thirty-three consecutive patients (22 men and 11 women; mean age ± SD, 57.8 ± 12.1 y) were investigated at baseline and again 3 mo after initiation of the first cycle of PRRT. 68Ga-DOTATATE receptor expression was assessed using 2 measures of standardized uptake value (SUV): maximum SUV (SUVmax) and tumor-to-spleen SUV ratio (SUVT/S). Percentage change in SUV scores after PRRT relative to baseline (ΔSUV) was calculated. After completing 1–3 cycles of PRRT, patients entered the follow-up study, for estimation of time to progression. According to the Response Evaluation Criteria in Solid Tumors, progression was defined on the basis of contrast-enhanced CT. Clinical symptoms, as well as the tumor markers chromogranin A and neuron-specific enolase, were also recorded during regular follow-up visits. Results: The 23 of 31 patients with decreased SUVT/S after the first PRRT cycle had longer progression-free survival than did the 8 of 31 patients with stable or increased scores (median survival not reached vs. 6 mo, P = 0.002). For the 18 of 33 patients showing a reduction in SUVmax, there was no significant difference in progression-free survival (median survival not reached vs. 14 mo, P = 0.22). Multivariate regression analysis identified SUVT/S as the only independent predictor for tumor progression during follow-up. In the 17 of 33 patients with clinical symptoms before PRRT, ΔSUVT/S correlated with clinical improvement (r = 0.52, P &lt; 0.05), whereas ΔSUVmax did not (r = 0.42, P = 0.10). Changes in the tumor markers (chromogranin A and neuron-specific enolase) did not predict ΔSUV scores, clinical improvement, or time to progression. Conclusion: Decreased 68Ga-DOTATATE uptake in tumors after the first cycle of PRRT predicted time to progression and correlated with an improvement in clinical symptoms among patients with well-differentiated neuroendocrine tumors; ΔSUVT/S was superior to ΔSUVmax for prediction of outcome.