RT Journal Article
SR Electronic
T1 Added Value of Intraoperative Real-Time Imaging in Searches for Difficult-to-Locate Sentinel Nodes
JF Journal of Nuclear Medicine
JO J Nucl Med
FD Society of Nuclear Medicine
SP 1219
OP 1225
DO 10.2967/jnumed.110.074880
VO 51
IS 8
A1 Vidal-Sicart, Sergi
A1 Paredes, Pilar
A1 Zanón, Gabriel
A1 Pahisa, Jaume
A1 Martinez-Román, Sergio
A1 Caparrós, Xavier
A1 Vilalta, Antoni
A1 Rull, Ramon
A1 Pons, Francesca
YR 2010
UL http://jnm.snmjournals.org/content/51/8/1219.abstract
AB Localization of sentinel lymph nodes can be challenging if they are in difficult anatomic locations or near high radiotracer activity. The purpose of this study was to assess the value of intraoperative real-time imaging using a portable γ-camera in conjunction with a conventional γ-counting probe when it is difficult to localize the sentinel node. Methods: After 99mTc-nanocolloid injection, patients with various malignancies underwent presurgical lymphoscintigraphy followed by surgery (usually the next day). We evaluated 20 patients who required sentinel lymph node biopsy and in whom the location or other characteristics of the sentinel node would make intraoperative retrieval difficult. During surgery, the sentinel node was localized using a portable γ-camera together with a hand-held γ-probe. A 153Gd pointer or 125I seed was used to better depict the sentinel node location in real time. Results: Using only a conventional hand-held γ-probe, surgeons were able to definitively localize the sentinel node in 15 of 20 patients. Intraoperatively, the portable γ-camera showed uptake by the definite sentinel node in 19 of 20 patients and helped to precisely localize the node with the hand-held γ-probe in 4 patients. In 1 of these patients, the sentinel node was metastatic. Conclusion: The combination of a standard hand-held γ-probe and real-time imaging provided by a portable γ-camera offers a high intraoperative detection rate in patients with difficult sentinel node localization as assessed by presurgical lymphoscintigraphy.