RT Journal Article
SR Electronic
T1 The <em>XbaI</em> G&gt;T Polymorphism of the Glucose Transporter 1 Gene Modulates <sup>18</sup>F-FDG Uptake and Tumor Aggressiveness in Breast Cancer
JF Journal of Nuclear Medicine
JO J Nucl Med
FD Society of Nuclear Medicine
SP 1191
OP 1197
DO 10.2967/jnumed.110.075721
VO 51
IS 8
A1 Florian Grabellus
A1 Sien-Yi Sheu
A1 Hagen S. Bachmann
A1 Nils Lehmann
A1 Friedrich Otterbach
A1 Till A. Heusner
A1 Gerald Antoch
A1 Andreas Bockisch
A1 Rainer Kimmig
A1 Kurt W. Schmid
A1 Alexander R. Stahl
YR 2010
UL http://jnm.snmjournals.org/content/51/8/1191.abstract
AB We investigated the relevance of single-nucleotide polymorphisms (SNPs) in the glucose transporter 1 (GLUT1) gene to the uptake of 18F-FDG and tumor aggressiveness in breast cancer. Methods: In 52 individuals with breast cancer, a diagnostic PET/CT scan was obtained, and the standardized uptake value was determined as a measure of 18F-FDG uptake using a region-of-interest technique. Three GLUT1 SNPs (XbaI G&gt;T, HpyCH4V A&gt;T, and HaeIII T&gt;C) were investigated in genomic DNA that was isolated from the paraffin-embedded specimens of all patients. Tumors were typed and graded according to the World Health Organization classifications. Results: The GG genotype of the XbaI G&gt;T SNP was associated with increased tumor uptake of 18F-FDG, with a mean standardized uptake value of 11.7 (TT/GT genotypes, 5.9; P = 0.03). Furthermore, the GG genotype was positively related to enhanced tumor proliferation (mitotic count, P = 0.01). In line with this finding, the GG genotype was absent in grade 1 carcinomas and increasingly prevalent in tumors with higher malignancy (grade 2, 28.0%; grade 3, 50%; P = 0.04). Conclusion: This study found that the XbaI G&gt;T SNP of the GLUT1 gene is associated with an increased 18F-FDG uptake and a more advanced tumor grade or growth in breast cancer. Thus, this genetic variant might favor aggressive phenotypes by modulating the efficiency of cancer cells to recruit glucose and escalate growth rate, suggesting the XbaI G&gt;T SNP as a proliferation-related prognostic factor.