PT  - JOURNAL ARTICLE
AU  - Florian Grabellus
AU  - Sien-Yi Sheu
AU  - Hagen S. Bachmann
AU  - Nils Lehmann
AU  - Friedrich Otterbach
AU  - Till A. Heusner
AU  - Gerald Antoch
AU  - Andreas Bockisch
AU  - Rainer Kimmig
AU  - Kurt W. Schmid
AU  - Alexander R. Stahl
TI  - The <em>XbaI</em> G>T Polymorphism of the Glucose Transporter 1 Gene Modulates <sup>18</sup>F-FDG Uptake and Tumor Aggressiveness in Breast Cancer
AID  - 10.2967/jnumed.110.075721
DP  - 2010 Aug 01
TA  - Journal of Nuclear Medicine
PG  - 1191--1197
VI  - 51
IP  - 8
4099  - http://jnm.snmjournals.org/content/51/8/1191.short
4100  - http://jnm.snmjournals.org/content/51/8/1191.full
SO  - J Nucl Med2010 Aug 01; 51
AB  - We investigated the relevance of single-nucleotide polymorphisms (SNPs) in the glucose transporter 1 (GLUT1) gene to the uptake of 18F-FDG and tumor aggressiveness in breast cancer. Methods: In 52 individuals with breast cancer, a diagnostic PET/CT scan was obtained, and the standardized uptake value was determined as a measure of 18F-FDG uptake using a region-of-interest technique. Three GLUT1 SNPs (XbaI G>T, HpyCH4V A>T, and HaeIII T>C) were investigated in genomic DNA that was isolated from the paraffin-embedded specimens of all patients. Tumors were typed and graded according to the World Health Organization classifications. Results: The GG genotype of the XbaI G>T SNP was associated with increased tumor uptake of 18F-FDG, with a mean standardized uptake value of 11.7 (TT/GT genotypes, 5.9; P = 0.03). Furthermore, the GG genotype was positively related to enhanced tumor proliferation (mitotic count, P = 0.01). In line with this finding, the GG genotype was absent in grade 1 carcinomas and increasingly prevalent in tumors with higher malignancy (grade 2, 28.0%; grade 3, 50%; P = 0.04). Conclusion: This study found that the XbaI G>T SNP of the GLUT1 gene is associated with an increased 18F-FDG uptake and a more advanced tumor grade or growth in breast cancer. Thus, this genetic variant might favor aggressive phenotypes by modulating the efficiency of cancer cells to recruit glucose and escalate growth rate, suggesting the XbaI G>T SNP as a proliferation-related prognostic factor.