RT Journal Article
SR Electronic
T1 Nephrotoxicity in Mice After Repeated Imaging Using <sup>111</sup>In-Labeled Peptides
JF Journal of Nuclear Medicine
JO J Nucl Med
FD Society of Nuclear Medicine
SP 973
OP 977
DO 10.2967/jnumed.109.074310
VO 51
IS 6
A1 Melis, Marleen
A1 Vegt, Erik
A1 Konijnenberg, Mark W.
A1 de Visser, Monique
A1 Bijster, Magda
A1 Vermeij, Marcel
A1 Krenning, Eric P.
A1 Boerman, Otto C.
A1 de Jong, Marion
YR 2010
UL http://jnm.snmjournals.org/content/51/6/973.abstract
AB We determined the renal radiation dose of a series of 111In-labeled peptides using animal SPECT. Because the animals' health deteriorated, renal toxicity was assessed. Methods: Wild-type and megalin-deficient mice were imaged repeatedly at 3- to 6-wk intervals to quantify renal retention after injection of 40–50 MBq of 111In-diethylenetriaminepentaacetic acid–labeled peptides (octreotide, exendin, octreotate, neurotensin, and minigastrin analogs), and the absorbed kidney radiation doses were estimated. Body weight, renal function parameters, and renal histology were determined at 16–20 wk after the first scan and compared with those in naive animals. Results: Because of high renal retention, 111In-diethylenetriaminepentaacetic acid–exendin-4 scans resulted in a 70-Gy kidney radiation dose in wild-type mice. Megalin-deficient kidneys received 20–40 Gy. The other peptides resulted in much lower renal doses. Kidney function monitoring indicated renal damage in imaged animals. Conclusion: Micro-SPECT enables longitudinal studies in 1 animal. However, long-term nephrotoxic effects may be induced after high renal radiation doses, even with 111In-labeled radiotracers.