RT Journal Article SR Electronic T1 Feasibility of 18F-Sodium Fluoride PET/CT for Imaging of Atherosclerotic Plaque JF Journal of Nuclear Medicine JO J Nucl Med FD Society of Nuclear Medicine SP 862 OP 865 DO 10.2967/jnumed.110.076471 VO 51 IS 6 A1 Derlin, Thorsten A1 Richter, Ulrich A1 Bannas, Peter A1 Begemann, Philipp A1 Buchert, Ralph A1 Mester, Janos A1 Klutmann, Susanne YR 2010 UL http://jnm.snmjournals.org/content/51/6/862.abstract AB The aim of this study was to examine the prevalence, distribution, and topographic relationship of vascular 18F-sodium fluoride uptake and arterial calcification in major arteries. Methods: Image data obtained from 75 patients undergoing whole-body 18F-sodium fluoride PET/CT were evaluated retrospectively. Arterial radiotracer uptake and calcification were analyzed qualitatively and semiquantitatively. Results: 18F-sodium fluoride uptake was observed at 254 sites in 57 (76%) of the 75 study patients, and calcification was observed at 1,930 sites in 63 (84%) of the patients. Colocalization of radiotracer accumulation and calcification could be observed in 223 areas of uptake (88%). However, only 12% of all arterial calcification sites showed increased radiotracer uptake. Conclusion: Our data indicate the feasibility of 18F-sodium fluoride PET/CT for the imaging of mineral deposition in arterial wall alterations. 18F-sodium fluoride PET/CT may provide relevant information about the morphologic and functional properties of calcified plaque.