RT Journal Article
SR Electronic
T1 Nuclear Imaging Techniques for the Assessment of Hepatic Function in Liver Surgery and Transplantation
JF Journal of Nuclear Medicine
JO J Nucl Med
FD Society of Nuclear Medicine
SP 742
OP 752
DO 10.2967/jnumed.109.069435
VO 51
IS 5
A1 de Graaf, Wilmar
A1 Bennink, Roelof J.
A1 Veteläinen, Reeta
A1 van Gulik, Thomas M.
YR 2010
UL http://jnm.snmjournals.org/content/51/5/742.abstract
AB This review describes the application of 2 nuclear imaging techniques for assessment of hepatic function in the setting of liver surgery and transplantation. The biochemical and technical background, as well as the clinical applications, of 99mTc-labeled diethylenetriaminepentaacetic acid galactosyl human serum albumin (GSA) scintigraphy and hepatobiliary scintigraphy (HBS) with 99mTc-labeled iminodiacetic acid derivates is discussed. 99mTc-mebrofenin is considered the most suitable iminodiacetic acid agent for 99mTc-HBS. 99mTc-GSA scintigraphy and 99mTc-mebrofenin HBS are based on 2 different principles. 99mTc-GSA scintigraphy is a receptor-mediated technique whereas HBS represents hepatic uptake and excretion function. Both techniques are noninvasive and provide visual and quantitative information on both total and regional liver function. They can be used for preoperative assessment of future remnant liver function, follow-up after preoperative portal vein embolization, and evaluation of postoperative liver regeneration. In liver transplantation, these methods are used to assess graft function and biliary complications.