PT  - JOURNAL ARTICLE
AU  - Nanni, Cristina
AU  - Errani, Costantino
AU  - Boriani, Luca
AU  - Fantini, Lorenzo
AU  - Ambrosini, Valentina
AU  - Boschi, Stefano
AU  - Rubello, Domenico
AU  - Pettinato, Cinzia
AU  - Mercuri, Mario
AU  - Gasbarrini, Alessandro
AU  - Fanti, Stefano
TI  - <sup>68</sup>Ga-Citrate PET/CT for Evaluating Patients with Infections of the Bone: Preliminary Results
AID  - 10.2967/jnumed.110.080184
DP  - 2010 Dec 01
TA  - Journal of Nuclear Medicine
PG  - 1932--1936
VI  - 51
IP  - 12
4099  - http://jnm.snmjournals.org/content/51/12/1932.short
4100  - http://jnm.snmjournals.org/content/51/12/1932.full
SO  - J Nucl Med2010 Dec 01; 51
AB  - The aim of this work was to preliminarily evaluate the sensitivity, specificity, positive predictive value, negative predictive value, and overall accuracy of 68Ga-citrate PET/CT in a population of patients with suspected bone infections. Methods: We enrolled 31 patients with suspected osteomyelitis or diskitis who underwent a total of forty 68Ga-citrate PET/CT scans. The results were compared with different combinations of diagnostic procedures (MRI, radiography, CT, or white blood cell scintigraphy), biopsy (when diagnostic), and follow-up data (at least 1 y) to determine the performance of 68Ga-citrate PET/CT. Results: We found a sensitivity of 100%, a specificity of 76%, a positive predictive value of 85%, a negative predictive value of 100%, and an overall accuracy of 90%. Conclusion: Although preliminary, these data confirm a possible role for 68Ga-citrate in the diagnosis of bone infections, especially in consideration of its favorable characteristics.