PT  - JOURNAL ARTICLE
AU  - Alexiou, George A.
AU  - Tsiouris, Spyridon
AU  - Kyritsis, Athanasios P.
AU  - Fotakopoulos, George
AU  - Goussia, Anna
AU  - Voulgaris, Spyridon
AU  - Fotopoulos, Andreas D.
TI  - The Value of <sup>99m</sup>Tc-Tetrofosmin Brain SPECT in Predicting Survival in Patients with Glioblastoma Multiforme
AID  - 10.2967/jnumed.110.080929
DP  - 2010 Dec 01
TA  - Journal of Nuclear Medicine
PG  - 1923--1926
VI  - 51
IP  - 12
4099  - http://jnm.snmjournals.org/content/51/12/1923.short
4100  - http://jnm.snmjournals.org/content/51/12/1923.full
SO  - J Nucl Med2010 Dec 01; 51
AB  - 99mTc-tetrofosmin brain SPECT has been reported as a useful tool for the evaluation of glioma proliferation. In the present study, we set out to investigate the prognostic value of 99mTc-tetrofosmin brain SPECT in patients with glioblastoma multiforme. Methods: We prospectively studied 18 patients (13 men, 5 women; mean age ± SD, 60.8 ± 7.79 y) who were operated on for glioblastoma multiforme. All patients underwent preoperative 99mTc-tetrofosmin brain SPECT, and surgical excision was performed within a week after SPECT. All patients received postoperative radiotherapy and chemotherapy. Results: By calculating the lesion-to-normal (L/N) 99mTc-tetrofosmin uptake ratio, we found that patients with an L/N ratio of more than 4.7 had significantly worse survival than did patients with an L/N ratio of 4.7 or less. Furthermore, patients with a Karnofsky Performance Score more than 90 had a significantly better survival rate. Although patients with near-total tumor resection who were younger than 60 y survived longer, the difference did not reach statistical significance. In the multivariate analysis, 99mTc-tetrofosmin uptake and Karnofsky Performance Score were identified as factors with independent prognostic power. Conclusion: 99mTc-tetrofosmin brain SPECT may be an independent prognostic factor in patients with glioblastoma multiforme. Further larger studies are needed to verify these results.