PT  - JOURNAL ARTICLE
AU  - Heute, Dirk
AU  - Kostron, Herwig
AU  - von Guggenberg, Elisabeth
AU  - Ingorokva, Shota
AU  - Gabriel, Michael
AU  - Dobrozemsky, Georg
AU  - Stockhammer, Günther
AU  - Virgolini, Irene J.
TI  - Response of Recurrent High-Grade Glioma to Treatment with <sup>90</sup>Y-DOTATOC
AID  - 10.2967/jnumed.109.072819
DP  - 2010 Mar 01
TA  - Journal of Nuclear Medicine
PG  - 397--400
VI  - 51
IP  - 3
4099  - http://jnm.snmjournals.org/content/51/3/397.short
4100  - http://jnm.snmjournals.org/content/51/3/397.full
SO  - J Nucl Med2010 Mar 01; 51
AB  - The treatment of patients with high-grade malignant glioma still represents an unsolved clinical problem. We report the treatment of 3 patients who had World Health Organization grade IV recurrent glioblastoma: a 23-y-old woman and 2 men aged 61 and 62 y. Methods: All 3 patients were treated with the somatostatin receptor radiopharmaceutical 90Y-labeled [1,4,7,10-tetraazacyclododecane-N,N′,N″,N″′-tetraacetic acid0-d-Phe1,Tyr3]octreotide (DOTATOC). A cumulated dose of 1.7–2.2 GBq given in 3 or 4 cycles was locally injected into a previously implanted catheter system. Results: Treatment was successful in all 3 patients, with only minor side effects reported. After treatment, MRI and PET showed complete remission in one patient and partial remission in the other patients. These findings correlated well with clinical improvement and improved quality of life. Conclusion: Receptor-mediated radionuclide therapy by locally injected 90Y-DOTATOC is feasible and well tolerated. This approach represents an attractive strategy for the treatment of locally recurring or progressing glioblastoma.