PT  - JOURNAL ARTICLE
AU  - George Sgouros
AU  - John C. Roeske
AU  - Michael R. McDevitt
AU  - Stig Palm
AU  - Barry J. Allen
AU  - Darrell R. Fisher
AU  - A. Bertrand Brill
AU  - Hong Song
AU  - Roger W. Howell
AU  - Gamal Akabani
ED  - ,
TI  - MIRD Pamphlet No. 22 (Abridged): Radiobiology and Dosimetry of α-Particle Emitters for Targeted Radionuclide Therapy
AID  - 10.2967/jnumed.108.058651
DP  - 2010 Feb 01
TA  - Journal of Nuclear Medicine
PG  - 311--328
VI  - 51
IP  - 2
4099  - http://jnm.snmjournals.org/content/51/2/311.short
4100  - http://jnm.snmjournals.org/content/51/2/311.full
SO  - J Nucl Med2010 Feb 01; 51
AB  - The potential of α-particle emitters to treat cancer has been recognized since the early 1900s. Advances in the targeted delivery of radionuclides and radionuclide conjugation chemistry, and the increased availability of α-emitters appropriate for clinical use, have recently led to patient trials of radiopharmaceuticals labeled with α-particle emitters. Although α-emitters have been studied for many decades, their current use in humans for targeted therapy is an important milestone. The objective of this work is to review those aspects of the field that are pertinent to targeted α-particle emitter therapy and to provide guidance and recommendations for human α-particle emitter dosimetry.