PT  - JOURNAL ARTICLE
AU  - Chen, Libo
AU  - Li, Fang
AU  - Zhuang, Hongming
AU  - Jing, Hongli
AU  - Du, Yanrong
AU  - Zeng, Zhengpei
TI  - <sup>99m</sup>Tc-HYNIC-TOC Scintigraphy Is Superior to <sup>131</sup>I-MIBG Imaging in the Evaluation of Extraadrenal Pheochromocytoma
AID  - 10.2967/jnumed.108.058693
DP  - 2009 Mar 01
TA  - Journal of Nuclear Medicine
PG  - 397--400
VI  - 50
IP  - 3
4099  - http://jnm.snmjournals.org/content/50/3/397.short
4100  - http://jnm.snmjournals.org/content/50/3/397.full
SO  - J Nucl Med2009 Mar 01; 50
AB  - In this investigation, the efficacy of scintigraphy using 99mTc-labeled hydrazinonicotinyl-Tyr3-octreotide (HYNIC-TOC) in the evaluation of extraadrenal pheochromocytoma was assessed and compared with 131I-labeled metaiodobenzylguanidine (MIBG) imaging. Methods: Ninety-seven patients who were suspected of having pheochromocytoma but showed no definite adrenal abnormalities on CT were evaluated by both 99mTc-HYNIC-TOC scintigraphy and 131I-MIBG imaging. The results were compared with pathology findings or clinical follow-up. Results: Of 58 patients proven to be without pheochromocytoma, 99mTc-HYNIC-TOC and 131I-MIBG imaging excluded 56 and 58 patients, respectively, rendering a specificity of 96.6% for 99mTc-HYNIC-TOC imaging and 100% for 131I-MIBG imaging. In the evaluation of adrenal pheochromocytoma (14 patients), the sensitivity of 99mTc-HYNIC-TOC scintigraphy and 131I-MIBG imaging was 50% and 85.7%, respectively. However, in the evaluation of extraadrenal pheochromocytomas (25 patients), the sensitivity of 99mTc-HYNIC-TOC scintigraphy and 131I-MIBG imaging was 96.0% and 72.0%, respectively. Conclusion: 99mTc-HYNIC-TOC scintigraphy is more sensitive than 131I-MIBG imaging in the detection of extraadrenal pheochromocytomas.