RT Journal Article
SR Electronic
T1 Substructural Hippocampal Glucose Metabolism Observed on PET/MRI
JF Journal of Nuclear Medicine
JO J Nucl Med
FD Society of Nuclear Medicine
SP 1545
OP 1548
DO 10.2967/jnumed.110.076182
VO 51
IS 10
A1 Zang-Hee Cho
A1 Young-Don Son
A1 Hang-Keun Kim
A1 Sung-Tae Kim
A1 Sang-Yoon Lee
A1 Je-Geun Chi
A1 Chan-Woong Park
A1 Young-Bo Kim
YR 2010
UL http://jnm.snmjournals.org/content/51/10/1545.abstract
AB The hippocampus is one of the best-known neural structures in the brain and has been of interest in observing the substructures and their metabolic functions. However, it has been difficult to distinguish its substructures and functions in vivo because of its small size. Methods: 18F-FDG PET and high-resolution MRI of the hippocampus were performed on 5 healthy subjects using a PET/MRI system. The metabolism of each hippocampal substructure was measured in vivo on the basis of the MR images. Results: The dentate gyrus and cornu ammonis 4 showed the highest glucose uptake in the healthy subjects. Conclusion: Measuring glucose metabolism in the substructures of the hippocampus could provide a new tool for the future investigation of related brain diseases or functional studies, such as Alzheimer disease or memory and learning studies.