RT Journal Article
SR Electronic
T1 Standards for PET Image Acquisition and Quantitative Data Analysis
JF Journal of Nuclear Medicine
JO J Nucl Med
FD Society of Nuclear Medicine
SP 11S
OP 20S
DO 10.2967/jnumed.108.057182
VO 50
IS Suppl 1
A1 Ronald Boellaard
YR 2009
UL http://jnm.snmjournals.org/content/50/Suppl_1/11S.abstract
AB Quantitative 18F-FDG PET is increasingly being recognized as an important tool for diagnosis, determination of prognosis, and response monitoring in oncology. However, PET quantification with, for example, standardized uptake values (SUVs) is affected by many technical and physiologic factors. As a result, some of the variations in the literature on SUV-based patient outcomes are explained by differences in 18F-FDG PET study methods. Various technical and clinical studies have been performed to understand the factors affecting PET quantification. On the basis of the results of those studies, several recommendations and guidelines have been proposed with the aims of improving the image quality and the quantitative accuracy of 18F-FDG PET studies. In this contribution, an overview of recommendations and guidelines for quantitative 18F-FDG PET studies in oncology is provided. Special attention is given to the rationale underlying certain recommendations and to some of the differences in various guidelines.