RT Journal Article
SR Electronic
T1 Relationship of Cerebrospinal Fluid Markers to <sup>11</sup>C-PiB and <sup>18</sup>F-FDDNP Binding
JF Journal of Nuclear Medicine
JO J Nucl Med
FD Society of Nuclear Medicine
SP 1464
OP 1470
DO 10.2967/jnumed.109.064360
VO 50
IS 9
A1 Nelleke Tolboom
A1 Wiesje M. van der Flier
A1 Maqsood Yaqub
A1 Ronald Boellaard
A1 Nicolaas A. Verwey
A1 Marinus A. Blankenstein
A1 Albert D. Windhorst
A1 Philip Scheltens
A1 Adriaan A. Lammertsma
A1 Bart N.M. van Berckel
YR 2009
UL http://jnm.snmjournals.org/content/50/9/1464.abstract
AB The purpose of this study was to investigate the potential relationships between cerebrospinal fluid (CSF) measurements of β-amyloid-1–42 (Aβ1-42) and total tau to 11C-Pittsburgh compound B (11C-PiB) and 2-(1-{6-[(2-18F-fluoroethyl)(methyl)amino]-2-naphthyl}ethylidene) malononitrile (18F-FDDNP) binding as measured using PET. Methods: A total of 37 subjects were included, consisting of 15 patients with Alzheimer disease (AD), 12 patients with mild cognitive impairment, and 10 healthy controls. All subjects underwent a lumbar puncture and PET using both 11C-PiB and 18F-FDDNP. For both PET tracers, parametric images of binding potential were generated. Potential associations of CSF levels of Aβ1-42 and tau with 11C-PiB and 18F-FDDNP binding were assessed using Pearson correlation coefficients and linear regression analyses. Results: For both global 11C-PiB and 18F-FDDNP binding, significant correlations with CSF levels of Aβ1-42 (r = −0.72 and −0.37, respectively) and tau (r = 0.58 and 0.56, respectively) were found across groups (all P &lt; 0.001, except P &lt; 0.05 for correlation between 18F-FDDNP and Aβ1-42). Linear regression analyses showed that, adjusted for regional volume, age, sex, and diagnosis, global 11C-PiB uptake had an inverse association with Aβ1-42 CSF levels (standardized β = −0.50, P &lt; 0.001), whereas there was a positive association between global 18F-FDDNP binding and tau CSF levels (standardized β = 0.62, P &lt; 0.01). Conclusion: The good agreement between these 2 different types of biomarkers (i.e., CSF and PET) provides converging evidence for their validity. The inverse association between 11C-PiB and CSF tau Aβ1-42 confirms that 11C-PiB measures amyloid load in the brain. The positive association between 18F-FDDNP and CSF tau suggests that at least part of the specific signal of 18F-FDDNP in AD patients is due to tangle formation.