PT  - JOURNAL ARTICLE
AU  - Tolboom, Nelleke
AU  - van der Flier, Wiesje M.
AU  - Yaqub, Maqsood
AU  - Boellaard, Ronald
AU  - Verwey, Nicolaas A.
AU  - Blankenstein, Marinus A.
AU  - Windhorst, Albert D.
AU  - Scheltens, Philip
AU  - Lammertsma, Adriaan A.
AU  - van Berckel, Bart N.M.
TI  - Relationship of Cerebrospinal Fluid Markers to <sup>11</sup>C-PiB and <sup>18</sup>F-FDDNP Binding
AID  - 10.2967/jnumed.109.064360
DP  - 2009 Sep 01
TA  - Journal of Nuclear Medicine
PG  - 1464--1470
VI  - 50
IP  - 9
4099  - http://jnm.snmjournals.org/content/50/9/1464.short
4100  - http://jnm.snmjournals.org/content/50/9/1464.full
SO  - J Nucl Med2009 Sep 01; 50
AB  - The purpose of this study was to investigate the potential relationships between cerebrospinal fluid (CSF) measurements of β-amyloid-1–42 (Aβ1-42) and total tau to 11C-Pittsburgh compound B (11C-PiB) and 2-(1-{6-[(2-18F-fluoroethyl)(methyl)amino]-2-naphthyl}ethylidene) malononitrile (18F-FDDNP) binding as measured using PET. Methods: A total of 37 subjects were included, consisting of 15 patients with Alzheimer disease (AD), 12 patients with mild cognitive impairment, and 10 healthy controls. All subjects underwent a lumbar puncture and PET using both 11C-PiB and 18F-FDDNP. For both PET tracers, parametric images of binding potential were generated. Potential associations of CSF levels of Aβ1-42 and tau with 11C-PiB and 18F-FDDNP binding were assessed using Pearson correlation coefficients and linear regression analyses. Results: For both global 11C-PiB and 18F-FDDNP binding, significant correlations with CSF levels of Aβ1-42 (r = −0.72 and −0.37, respectively) and tau (r = 0.58 and 0.56, respectively) were found across groups (all P < 0.001, except P < 0.05 for correlation between 18F-FDDNP and Aβ1-42). Linear regression analyses showed that, adjusted for regional volume, age, sex, and diagnosis, global 11C-PiB uptake had an inverse association with Aβ1-42 CSF levels (standardized β = −0.50, P < 0.001), whereas there was a positive association between global 18F-FDDNP binding and tau CSF levels (standardized β = 0.62, P < 0.01). Conclusion: The good agreement between these 2 different types of biomarkers (i.e., CSF and PET) provides converging evidence for their validity. The inverse association between 11C-PiB and CSF tau Aβ1-42 confirms that 11C-PiB measures amyloid load in the brain. The positive association between 18F-FDDNP and CSF tau suggests that at least part of the specific signal of 18F-FDDNP in AD patients is due to tangle formation.