RT Journal Article SR Electronic T1 11C-Methionine PET of Acute Myocardial Infarction JF Journal of Nuclear Medicine JO J Nucl Med FD Society of Nuclear Medicine SP 1283 OP 1287 DO 10.2967/jnumed.108.061341 VO 50 IS 8 A1 Morooka, Miyako A1 Kubota, Kazuo A1 Kadowaki, Hiromu A1 Ito, Kimiteru A1 Okazaki, Osamu A1 Kashida, Mitsuo A1 Mitsumoto, Takuya A1 Iwata, Ren A1 Ohtomo, Kuni A1 Hiroe, Michiaki YR 2009 UL http://jnm.snmjournals.org/content/50/8/1283.abstract AB Tissue uptake of l-[methyl-11C]-methionine (11C-methionine) has been used to monitor amino acid metabolism and protein synthesis. We examined whether 11C-methionine was retained in areas of myocardial infarction after successful reperfusion. Methods: Nine patients with infarction in the left anterior descendent region underwent percutaneous transluminal coronary artery intervention within 24 h and 201Tl SPECT, 18F-FDG PET, and 11C-methionine PET within 2 wk of infarction onset. The standardized uptake values of the infarcted area and of the normal area were measured. Results: The 11C-methionine images showed increased uptake in the infarcted area, whereas the 201Tl SPECT and 18F-FDG PET images showed decreased uptake. The highest accumulation of 11C-methionine in the infarcted area was observed during the early phase of AMI. Conclusion: 11C-methionine uptake is elevated in infarcted areas and may reflect the early acute phase of damage healing, that is, the initial process of remodeling.