TY - JOUR T1 - <sup>11</sup>C-Methionine PET of Acute Myocardial Infarction JF - Journal of Nuclear Medicine JO - J Nucl Med SP - 1283 LP - 1287 DO - 10.2967/jnumed.108.061341 VL - 50 IS - 8 AU - Miyako Morooka AU - Kazuo Kubota AU - Hiromu Kadowaki AU - Kimiteru Ito AU - Osamu Okazaki AU - Mitsuo Kashida AU - Takuya Mitsumoto AU - Ren Iwata AU - Kuni Ohtomo AU - Michiaki Hiroe Y1 - 2009/08/01 UR - http://jnm.snmjournals.org/content/50/8/1283.abstract N2 - Tissue uptake of l-[methyl-11C]-methionine (11C-methionine) has been used to monitor amino acid metabolism and protein synthesis. We examined whether 11C-methionine was retained in areas of myocardial infarction after successful reperfusion. Methods: Nine patients with infarction in the left anterior descendent region underwent percutaneous transluminal coronary artery intervention within 24 h and 201Tl SPECT, 18F-FDG PET, and 11C-methionine PET within 2 wk of infarction onset. The standardized uptake values of the infarcted area and of the normal area were measured. Results: The 11C-methionine images showed increased uptake in the infarcted area, whereas the 201Tl SPECT and 18F-FDG PET images showed decreased uptake. The highest accumulation of 11C-methionine in the infarcted area was observed during the early phase of AMI. Conclusion: 11C-methionine uptake is elevated in infarcted areas and may reflect the early acute phase of damage healing, that is, the initial process of remodeling. ER -