PT  - JOURNAL ARTICLE
AU  - Morooka, Miyako
AU  - Kubota, Kazuo
AU  - Kadowaki, Hiromu
AU  - Ito, Kimiteru
AU  - Okazaki, Osamu
AU  - Kashida, Mitsuo
AU  - Mitsumoto, Takuya
AU  - Iwata, Ren
AU  - Ohtomo, Kuni
AU  - Hiroe, Michiaki
TI  - <sup>11</sup>C-Methionine PET of Acute Myocardial Infarction
AID  - 10.2967/jnumed.108.061341
DP  - 2009 Aug 01
TA  - Journal of Nuclear Medicine
PG  - 1283--1287
VI  - 50
IP  - 8
4099  - http://jnm.snmjournals.org/content/50/8/1283.short
4100  - http://jnm.snmjournals.org/content/50/8/1283.full
SO  - J Nucl Med2009 Aug 01; 50
AB  - Tissue uptake of l-[methyl-11C]-methionine (11C-methionine) has been used to monitor amino acid metabolism and protein synthesis. We examined whether 11C-methionine was retained in areas of myocardial infarction after successful reperfusion. Methods: Nine patients with infarction in the left anterior descendent region underwent percutaneous transluminal coronary artery intervention within 24 h and 201Tl SPECT, 18F-FDG PET, and 11C-methionine PET within 2 wk of infarction onset. The standardized uptake values of the infarcted area and of the normal area were measured. Results: The 11C-methionine images showed increased uptake in the infarcted area, whereas the 201Tl SPECT and 18F-FDG PET images showed decreased uptake. The highest accumulation of 11C-methionine in the infarcted area was observed during the early phase of AMI. Conclusion: 11C-methionine uptake is elevated in infarcted areas and may reflect the early acute phase of damage healing, that is, the initial process of remodeling.