RT Journal Article
SR Electronic
T1 Strategies for Molecular Imaging of Epidermal Growth Factor Receptor Tyrosine Kinase in Cancer
JF Journal of Nuclear Medicine
JO J Nucl Med
FD Society of Nuclear Medicine
SP 1199
OP 1202
DO 10.2967/jnumed.109.062117
VO 50
IS 8
A1 Mishani, Eyal
A1 Hagooly, Aviv
YR 2009
UL http://jnm.snmjournals.org/content/50/8/1199.abstract
AB A wealth of research has focused on developing targeted cancer therapies by specifically inhibiting epidermal growth factor receptor tyrosine kinase (EGFR-TK). However, the outcome of most EGFR-TK–targeted drugs that were approved by the Food and Drug Administration or entered clinical trials has been only moderate. Enhancement of EGFR-targeted therapy hinges on a reliable in vivo quantitative molecular imaging method. Such a method would enable monitoring of receptor drug binding and receptor occupancy in vivo; determination of the duration of EGFR inhibition in vivo; and, potentially, identification of a primary or secondary mutation in EGFR leading to drug interaction or loss of EGFR recognition by the drug. This review analyzes the most recent strategies to visualize and quantify EGFR-TK in cancer by nuclear medicine imaging and describes future directions.