RT Journal Article
SR Electronic
T1 Uptake of <sup>18</sup>F-Labeled 6-Fluoro-6-Deoxy-<span class="sc">d</span>-Glucose by Skeletal Muscle Is Responsive to Insulin Stimulation
JF Journal of Nuclear Medicine
JO J Nucl Med
FD Society of Nuclear Medicine
SP 912
OP 919
DO 10.2967/jnumed.109.062687
VO 50
IS 6
A1 Spring-Robinson, Chandra
A1 Chandramouli, Visvanathan
A1 Schumann, William C.
A1 Faulhaber, Peter F.
A1 Wang, Yanming
A1 Wu, Chunying
A1 Ismail-Beigi, Faramarz
A1 Muzic, Raymond F.
YR 2009
UL http://jnm.snmjournals.org/content/50/6/912.abstract
AB We are developing a methodology for the noninvasive imaging of glucose transport in vivo with PET and 18F-labeled 6-fluoro-6-deoxy-d-glucose (18F-6FDG), a tracer that is transported but not phosphorylated. To validate the method, we evaluated the biodistribution of 18F-6FDG to test whether it is consistent with the known properties of glucose transport, particularly with regard to insulin stimulation of glucose transport. Methods: Under glucose clamp conditions, rats were imaged at the baseline and under conditions of hyperinsulinemia. Results: The images showed that the radioactivity concentration in skeletal muscle was higher in the presence of insulin than at the baseline. We also found evidence that the metabolism of 18F-6FDG was negligible in several tissues. Conclusion: 18F-6FDG is a valid tracer that can be used in in vivo transport studies. PET studies performed under glucose clamp conditions demonstrated that the uptake of nonphosphorylated glucose transport tracer 18F-6FDG is sensitive to insulin stimulation.