PT  - JOURNAL ARTICLE
AU  - Chandra Spring-Robinson
AU  - Visvanathan Chandramouli
AU  - William C. Schumann
AU  - Peter F. Faulhaber
AU  - Yanming Wang
AU  - Chunying Wu
AU  - Faramarz Ismail-Beigi
AU  - Raymond F. Muzic, Jr.
TI  - Uptake of <sup>18</sup>F-Labeled 6-Fluoro-6-Deoxy-<span class="sc">d</span>-Glucose by Skeletal Muscle Is Responsive to Insulin Stimulation
AID  - 10.2967/jnumed.109.062687
DP  - 2009 Jun 01
TA  - Journal of Nuclear Medicine
PG  - 912--919
VI  - 50
IP  - 6
4099  - http://jnm.snmjournals.org/content/50/6/912.short
4100  - http://jnm.snmjournals.org/content/50/6/912.full
SO  - J Nucl Med2009 Jun 01; 50
AB  - We are developing a methodology for the noninvasive imaging of glucose transport in vivo with PET and 18F-labeled 6-fluoro-6-deoxy-d-glucose (18F-6FDG), a tracer that is transported but not phosphorylated. To validate the method, we evaluated the biodistribution of 18F-6FDG to test whether it is consistent with the known properties of glucose transport, particularly with regard to insulin stimulation of glucose transport. Methods: Under glucose clamp conditions, rats were imaged at the baseline and under conditions of hyperinsulinemia. Results: The images showed that the radioactivity concentration in skeletal muscle was higher in the presence of insulin than at the baseline. We also found evidence that the metabolism of 18F-6FDG was negligible in several tissues. Conclusion: 18F-6FDG is a valid tracer that can be used in in vivo transport studies. PET studies performed under glucose clamp conditions demonstrated that the uptake of nonphosphorylated glucose transport tracer 18F-6FDG is sensitive to insulin stimulation.