TY - JOUR T1 - SPECT/CT with <sup>99m</sup>Tc-MAA in Radioembolization with <sup>90</sup>Y Microspheres in Patients with Hepatocellular Cancer JF - Journal of Nuclear Medicine JO - J Nucl Med SP - 688 LP - 692 DO - 10.2967/jnumed.108.058347 VL - 50 IS - 5 AU - Monia E. Hamami AU - Thorsten D. Poeppel AU - Stephan Müller AU - Till Heusner AU - Andreas Bockisch AU - Philipp Hilgard AU - Gerald Antoch Y1 - 2009/05/01 UR - http://jnm.snmjournals.org/content/50/5/688.abstract N2 - Radioembolization with 90Y microspheres is a novel treatment for hepatic tumors. Generally, hepatic arteriography and 99mTc-macroaggregated albumin (MAA) scanning are performed before selective internal radiation therapy to detect extrahepatic shunting to the lung or the gastrointestinal tract. Whereas previous studies have used only planar or SPECT scans, the present study used 99mTc-MAA SPECT/CT scintigraphy (SPECT with integrated low-dose CT) to evaluate whether SPECT/CT and additional diagnostic contrast-enhanced CT before radioembolization with 90Y microspheres are superior to SPECT or planar imaging alone for detection of gastrointestinal shunting. Methods: In a prospective study, we enrolled 58 patients (mean age, 66 y; SD, 12 y; 10 women and 48 men) with hepatocellular carcinoma who underwent hepatic arteriography and scintigraphy with 99mTc-MAA using planar imaging, SPECT, and SPECT with integrated low-dose CT of the upper abdomen (acquired with a hybrid SPECT/CT camera). The ability of the different imaging modalities to detect extrahepatic MAA shunting was compared. Patient follow-up of a mean of 180 d served as the standard of reference. Results: Gastrointestinal shunting was revealed by planar imaging in 4, by SPECT in 9, and by SPECT/CT in 16 of the 68 examinations. For planar imaging, the sensitivity for detection of gastrointestinal shunting was 25%, the specificity 87%, and the accuracy 72%. For SPECT without CT, the sensitivity was 56%, the specificity 87%, and the accuracy 79%. SPECT with CT fusion had a sensitivity of 100%, a specificity of 94%, and an accuracy of 96%. In 3 patients, MAA deposits in the portal vein could accurately be attributed to tumor thrombus only with additional information from contrast-enhanced CT. The follow-up did not show any gastrointestinal complications. Conclusion: SPECT with integrated low-dose CT using 99mTc-MAA is beneficial in radioembolization with 90Y microspheres because it increases the sensitivity and specificity of 99mTc-MAA SPECT when detecting extrahepatic arterial shunting. The overall low risk of gastrointestinal complications in radioembolization may therefore be further reduced by SPECT/CT. ER -