RT Journal Article
SR Electronic
T1 A Novel High-Sensitivity Rapid-Acquisition Single-Photon Cardiac Imaging Camera
JF Journal of Nuclear Medicine
JO J Nucl Med
FD Society of Nuclear Medicine
SP 635
OP 643
DO 10.2967/jnumed.108.060020
VO 50
IS 4
A1 Gambhir, Sanjiv S.
A1 Berman, Daniel S.
A1 Ziffer, Jack
A1 Nagler, Michael
A1 Sandler, Martin
A1 Patton, Jim
A1 Hutton, Brian
A1 Sharir, Tali
A1 Haim, Shlomo Ben
A1 Haim, Simona Ben
YR 2009
UL http://jnm.snmjournals.org/content/50/4/635.abstract
AB This study described and validated a new solid-state single-photon γ-camera and compared it with a conventional-SPECT Anger camera. The compact new camera uses a unique method for localizing γ-photon information with a bank of 9 solid-state detector columns with tungsten collimators that rotate independently. Methods: Several phantom studies were performed comparing the new technology with conventional-SPECT technology. These included measurements of line sources and single- and dual-radionuclide studies of a torso phantom. Simulations were also performed using a cardiothoracic phantom. Furthermore, 18 patients were scanned with both the new camera and a conventional-SPECT camera. Results: The new camera had a count sensitivity that was 10 times higher than that of the conventional camera and a compensated spatial resolution that was moderately better. Dual-radionuclide studies using a phantom show the further potential of the new camera for a 2-tracer simultaneous acquisition. Two-minute clinical studies with the new camera and 11-min studies with the conventional camera qualitatively showed good-to-excellent image quality and improved myocardial edge definition for the new camera. Conclusion: These initial performance characteristics of a new solid-state single-photon γ-camera offer great promise for clinical dynamic SPECT protocols, with important implications for applications in nuclear cardiology and molecular imaging.