RT Journal Article
SR Electronic
T1 Repeatability of Rest and Hyperemic Myocardial Blood Flow Measurements with <sup>82</sup>Rb Dynamic PET
JF Journal of Nuclear Medicine
JO J Nucl Med
FD Society of Nuclear Medicine
SP 68
OP 71
DO 10.2967/jnumed.108.055673
VO 50
IS 1
A1 Manabe, Osamu
A1 Yoshinaga, Keiichiro
A1 Katoh, Chietsugu
A1 Naya, Masanao
A1 deKemp, Robert A.
A1 Tamaki, Nagara
YR 2009
UL http://jnm.snmjournals.org/content/50/1/68.abstract
AB The repeatability of rest and hyperemic myocardial blood flow (MBF) measurements using 82Rb PET has not been evaluated. The aim of this study was to investigate the short-term repeatability of such measurements. Methods: Fifteen healthy volunteers underwent rest and pharmacologic stress 82Rb PET, repeated 60 min apart. Results: There was no significant difference in repeated rest MBF (0.77 ± 0.25 vs. 0.82 ± 0.25 mL/min/g, P = 0.31; mean difference, 6.18% ± 12.22%) or repeated hyperemic MBF (3.35 ± 1.37 vs. 3.39 ± 1.37 mL/min/g, P = 0.81; mean difference, 1.17% ± 13.64%). The repeatability coefficients were 0.19 mL/min/g for rest MBF and 0.92 mL/min/g for hyperemia. Conclusion: MBF using 82Rb is highly reproducible using a same-day short-term repeatability protocol. Serial MBF measurements with 82Rb PET should have the ability to quantify the acute effects of therapeutic interventions on MBF.