PT  - JOURNAL ARTICLE
AU  - Osamu Manabe
AU  - Keiichiro Yoshinaga
AU  - Chietsugu Katoh
AU  - Masanao Naya
AU  - Robert A. deKemp
AU  - Nagara Tamaki
TI  - Repeatability of Rest and Hyperemic Myocardial Blood Flow Measurements with <sup>82</sup>Rb Dynamic PET
AID  - 10.2967/jnumed.108.055673
DP  - 2009 Jan 01
TA  - Journal of Nuclear Medicine
PG  - 68--71
VI  - 50
IP  - 1
4099  - http://jnm.snmjournals.org/content/50/1/68.short
4100  - http://jnm.snmjournals.org/content/50/1/68.full
SO  - J Nucl Med2009 Jan 01; 50
AB  - The repeatability of rest and hyperemic myocardial blood flow (MBF) measurements using 82Rb PET has not been evaluated. The aim of this study was to investigate the short-term repeatability of such measurements. Methods: Fifteen healthy volunteers underwent rest and pharmacologic stress 82Rb PET, repeated 60 min apart. Results: There was no significant difference in repeated rest MBF (0.77 ± 0.25 vs. 0.82 ± 0.25 mL/min/g, P = 0.31; mean difference, 6.18% ± 12.22%) or repeated hyperemic MBF (3.35 ± 1.37 vs. 3.39 ± 1.37 mL/min/g, P = 0.81; mean difference, 1.17% ± 13.64%). The repeatability coefficients were 0.19 mL/min/g for rest MBF and 0.92 mL/min/g for hyperemia. Conclusion: MBF using 82Rb is highly reproducible using a same-day short-term repeatability protocol. Serial MBF measurements with 82Rb PET should have the ability to quantify the acute effects of therapeutic interventions on MBF.