RT Journal Article
SR Electronic
T1 <sup>124</sup>I PET-Based 3D-RD Dosimetry for a Pediatric Thyroid Cancer Patient: Real-Time Treatment Planning and Methodologic Comparison
JF Journal of Nuclear Medicine
JO J Nucl Med
FD Society of Nuclear Medicine
SP 1844
OP 1847
DO 10.2967/jnumed.109.066738
VO 50
IS 11
A1 Hobbs, Robert F.
A1 Wahl, Richard L.
A1 Lodge, Martin A.
A1 Javadi, Mehrbod S.
A1 Cho, Steve Y.
A1 Chien, David T.
A1 Ewertz, Marge E.
A1 Esaias, Caroline E.
A1 Ladenson, Paul W.
A1 Sgouros, George
YR 2009
UL http://jnm.snmjournals.org/content/50/11/1844.abstract
AB Patient-specific 3-dimensional radiobiologic dosimetry (3D-RD) was used for 131I treatment planning for an 11-y-old girl with differentiated papillary thyroid cancer, heavy lung involvement, and cerebral metastases. 124I PET was used for pharmacokinetics. Calculation of the recommended administered activity, based on lung toxicity constraints, was performed in real time (i.e., during the data-acquisition interval). The results were available to the physician in time to influence treatment; these estimates were compared with conventional dosimetry methodologies. In subsequent, retrospective analyses, the 3D-RD calculations were expanded to include additional tumor dose estimates, and the conventional methodologies were reexamined to reveal the causes of the differences observed. A higher recommended administered activity than by an S-value–based method with a favorable clinical outcome was obtained. This approach permitted more aggressive treatment while adhering to patient-specific lung toxicity constraints. A retrospective analysis of the conventional methodologies with appropriate corrections yielded absorbed dose estimates consistent with 3D-RD.