RT Journal Article
SR Electronic
T1 The Advantages of Nanoparticles for PET
JF Journal of Nuclear Medicine
JO J Nucl Med
FD Society of Nuclear Medicine
SP 1743
OP 1746
DO 10.2967/jnumed.109.061846
VO 50
IS 11
A1 Michael J. Welch
A1 Craig J. Hawker
A1 Karen L. Wooley
YR 2009
UL http://jnm.snmjournals.org/content/50/11/1743.abstract
AB Nanoparticles have an advantage for molecular imaging in that many functionalities can be added to the surface and interior of the particle. This brief review focuses on the design of nanomaterials that take advantage of PET. An evolutionary approach is presented, leading to the optimization of the nanoparticle composition and structure to achieve controlled in vivo circulation and tissue-selective targeting. Organic and inorganic nanostructures are included. Nanoprobes for PET of angiogenesis and cancer are highlighted.