PT  - JOURNAL ARTICLE
AU  - Michael J. Welch
AU  - Craig J. Hawker
AU  - Karen L. Wooley
TI  - The Advantages of Nanoparticles for PET
AID  - 10.2967/jnumed.109.061846
DP  - 2009 Nov 01
TA  - Journal of Nuclear Medicine
PG  - 1743--1746
VI  - 50
IP  - 11
4099  - http://jnm.snmjournals.org/content/50/11/1743.short
4100  - http://jnm.snmjournals.org/content/50/11/1743.full
SO  - J Nucl Med2009 Nov 01; 50
AB  - Nanoparticles have an advantage for molecular imaging in that many functionalities can be added to the surface and interior of the particle. This brief review focuses on the design of nanomaterials that take advantage of PET. An evolutionary approach is presented, leading to the optimization of the nanoparticle composition and structure to achieve controlled in vivo circulation and tissue-selective targeting. Organic and inorganic nanostructures are included. Nanoprobes for PET of angiogenesis and cancer are highlighted.